Anti-ATG16L1 antibodies are used in the immunodetection of the protein autophagy related 16 like 1. In humans, the canonical protein has a reported length of 607 amino acid residues and a mass of 68.3 kDa. Its subcellular localization is in the membrane, lysosomes and cytoplasm. Up to 5 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the WD repeat ATG16 protein family, ATG16L1 is known to play an important role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP). Post-translational modifications have been described, including protein cleavage and phosphorylation. The ATG16L1 gene has been associated with the disease, Inflammatory bowel disease. Synonyms for this target antigen include ATG16A, ATG16L, IBD10, WDR30, autophagy-related protein 16-1, and APG16L. ATG16L1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.