Anti-RIPK3 antibodies are used in the immunodetection of the protein receptor interacting serine/threonine kinase 3. In humans, the canonical protein has a reported length of 518 amino acid residues and a mass of 56.9 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is reported to be highly expressed in the pancreas. A member of the TKL Ser/Thr protein kinase protein family, RIPK3 is a type of serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death. Post-translational modifications have been described, including ubiquitination, protein cleavage and phosphorylation. Synonyms for this target antigen include receptor-interacting serine/threonine-protein kinase 3, RIP-3, RIP-like protein kinase 3, receptor interacting protein 3, and RIP3. RIPK3 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species.