Anti-ataxin 7 like 3 antibodies are used in the immunodetection of the protein encoded by the ATXN7L3 gene. In humans, the canonical protein has a reported length of 347 amino acid residues and a mass of 38.7 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the SGF11 protein family, it is a known component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Other names for this target antigen include ataxin-7-like protein 3.