Anti-DEAD-box helicase 5 antibodies are used in the immunodetection of the protein encoded by the DDX5 gene. In humans, the canonical protein has a reported length of 614 amino acid residues and a mass of 69.1 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the DEAD box helicase protein family, it is reported to be involved in alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Post-translational modifications have been described, including methylation, ubiquitination, sumoylation and phosphorylation. Other names for this target antigen include HLR1, HUMP68, p68, probable ATP-dependent RNA helicase DDX5, ATP-dependent RNA helicase DDX5, and G17P1.