Anti-synoviolin 1 antibodies are used for the immunodetection of the protein encoded by the SYVN1 gene. In humans, the canonical protein has a reported length of 617 amino acid residues and a mass of 67.7 kDa. Its subcellular localization is in the ER. Alternative splicing is reported to yield 3 different isoforms for this protein. It is widely expressed across many tissue types. A member of the HRD1 protein family, it is known to be involved with immature B cell differentiation and the regulation of apoptosis. Post-translational modifications have been described, including N-glycosylation and ubiquitination. Other names for this target antigen include HMG-coA reductase degradation 1 homolog, RING-type E3 ubiquitin transferase synoviolin, synovial apoptosis inhibitor 1, synoviolin, and E3 ubiquitin-protein ligase synoviolin. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 90 citations in the literature describe the use of synoviolin 1 antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.