Anti-KMT2A antibodies are used in the immunodetection of the protein lysine methyltransferase 2A. In humans, the canonical protein has a reported length of 3969 amino acid residues and a mass of 431.8 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of a the Histone-lysine methyltransferase protein family, KMT2A is a known histone methyltransferase that plays an essential role in early development and hematopoiesis. Post-translational modifications have been described, including methylation, protein cleavage and phosphorylation. Synonyms for this target antigen include ALL1, CXXC7, GAS7, HRX, HTRX, HTRX1, MLL, and ALL-1.