Anti-ANXA2 antibodies are used in the immunodetection of the protein annexin A2. In humans, the canonical protein has a reported length of 339 amino acid residues and a mass of 38.6 kDa. Its subcellular localization is in the extracellular matrix and is secreted. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Annexin protein family, ANXA2 is known to be involved with angiogenesis. Post-translational modifications have been described, including phosphorylation.
The ANXA2 marker can be used to identify CD4 Memory T Cells.* Synonyms for this target antigen include ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, and ANX2. ANXA2 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 230 citations in the literature describe the use of ANXA2 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4