SMYD4 encodes the human gene, SET and MYND domain containing 4. It may also be known as: SET and MYND domain-containing protein 4; SET and MYND domain-containing protein 4 ; ZMYND21. The encoded protein is an enzyme with an amino acid length of 804 and a mass of 89.2 kDa. Other isoforms may exist. SMYD4 is a member of the Class V-like SAM-binding methyltransferase superfamily. Homologs of this gene exist in other organisms, including: Fly, Mouse, Rat, Zebrafish, Frog, Chicken.