Anti-Uroplakin 1A antibodies are used for the immunodetection of the protein encoded by the UPK1A gene. In humans, the canonical protein has a reported length of 258 amino acid residues and a mass of 28.9 kDa. Its subcellular localization is in the membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Tetraspanin (TM4SF) protein family, it is a known component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. Post-translational modifications have been described, including glycosylation.
The uroplakin 1A marker can be used to characterize Ureter Urothelium Superficial Cells.* Other names for this target antigen include UP1A, UPIA, UPKA, tetraspanin-21, tspan-21, uroplakin Ia, and TSPAN21. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish and chimpanzee species. A number of Uroplakin 1A antibodies have been mentioned in research publications and have associated citations. ELISA is a widely used application for these antibodies. Immunocytochemistry and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4