Anti-IDE antibodies are used in the immunodetection of the protein insulin degrading enzyme. In humans, the canonical protein has a reported length of 1019 amino acid residues and a mass of 118 kDa. Its subcellular localization is in the cell membrane, cytoplasm, and is secreted. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the brain and in cerebrospinal fluid. A member of the Peptidase M16 protein family, IDE is reported to play a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. Synonyms for this target antigen include Abeta-degrading protease, insulin protease, insulinase, and INSULYSIN. IDE gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 60 citations in the literature describe the use of IDE antibodies in research. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.