Anti-ISCA1 antibodies are used in the immunodetection of the protein iron-sulfur cluster assembly 1. In humans, the canonical protein has a reported length of 129 amino acid residues and a mass of 14.2 kDa. Its subcellular localization is in the mitochondria. Up to 2 different isoforms have been reported for this protein. It is notably expressed in cerebellum, kidney and heart. A member of the HesB/IscA protein family, Isca1 is reported to be involved in maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. The ISCA1 gene has been associated with the disease, Multiple mitochondrial dysfunctions syndrome. Synonyms for this target antigen include HESB like domain containing 2, HESB-like domain-containing protein 2, iron-sulfur assembly protein IscA, and iron-sulfur cluster assembly 1 homolog, mitochondrial. ISCA1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some Isca1 antibodies may have been used in research and have associated citations. ELISA is a widely used application for these antibodies. Western Blot and Immunofluorescence are also common applications.