Anti-APOE antibodies are used in the immunodetection of the protein apolipoprotein E. In humans, the canonical protein has a reported length of 317 amino acid residues and a mass of 36.2 kDa. Its subcellular localization is in the extracellular matrix and is secreted. It is notably expressed in many tissues, such as the adrenal gland and caudate. A member of the Apolipoprotein A1/A4/E protein family, APOE is known to be involved with cholesterol metabolism and homeostasis. Post-translational modifications have been described, including O-glycosylation, protein cleavage and phosphorylation. The APOE marker can be used to identify Brain Astrocytes, Mueller Cells, Macrophages, Red Pulp Macrophages, and Splenic Perifollicular Zone Macrophages.* Synonyms for this target antigen include ApoE4, LDLCQ5, LPG, apolipoprotein E3, and AD2. APOE gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4