Anti-STAC antibodies are used in the immunodetection of the protein SH3 and cysteine rich domain. In humans, the canonical protein has a reported length of 402 amino acid residues and a mass of 44.6 kDa. Its subcellular localization is in the cell membrane and cytoplasm. STAC is reported to promote expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. The STAC marker can be used to identify Gray Matter Medium Spiny Neurons.* Synonyms for this target antigen include SH3 and cysteine-rich domain-containing protein, SRC homology 3 and cysteine-rich domain-containing protein, and STAC1. STAC gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some Stac antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4