Anti-Glucokinase antibodies are used for the immunodetection of the protein encoded by the GCK gene. In humans, the canonical protein has a reported length of 465 amino acid residues and a mass of 52.2 kDa. Its subcellular localization is in the nucleus, mitochondria, and cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the Hexokinase protein family, it is known to catalyze the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively). The gene encoding this protein is implicated in Maturity-onset diabetes of the young. Other names for this target antigen include GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, and FGQTL3. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.