Anti-COL9A1 antibodies are used in the immunodetection of the protein collagen type IX alpha 1 chain. In humans, the canonical protein has a reported length of 921 amino acid residues and a mass of 91.9 kDa. Its subcellular localization is in the extracellular matrix and is secreted. Up to 3 different isoforms have been reported for this protein. It is notably expressed in the retina, kidney, and cartilage. A member of the Fibril-associated collagens with interrupted helices (FACIT) protein family, COL9A1 is reported to be a structural component of hyaline cartilage and vitreous of the eye.
The COL9A1 marker can be used to identify Deep-Layer Near-Projecting Neurons.* Synonyms for this target antigen include EDM6, MED, STL4, collagen alpha-1(IX) chain, alpha-1(IX) collagen chain, and DJ149L1.1.2. COL9A1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some COL9A1 antibodies may have been used in research and have associated citations. ELISA, Western Blot, and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4