Anti-C10orf90 antibodies are used in the immunodetection of the protein chromosome 10 open reading frame 90. In humans, the canonical protein has a reported length of 699 amino acid residues and a mass of 77.9 kDa. Its subcellular localization is in the cytoplasm. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the testis. C10orf90 is reported to be a tumor suppressor that is required to sustain G2/M checkpoint after DNA damage.
The C10orf90 marker can be used to identify Cerebral Cortex Neurons.* Synonyms for this target antigen include E2/E3 hybrid ubiquitin-protein ligase FATS, centrosomal protein C10orf90, fragile-site associated tumor suppressor homolog, and (E2-independent) E3 ubiquitin-conjugating enzyme FATS. C10orf90 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some C10orf90 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4