Anti-Desmoglein 1 antibodies are used for the immunodetection of the protein encoded by the DSG1 gene. In humans, the canonical protein has a reported length of 1049 amino acid residues and a mass of 113.7 kDa. Its subcellular localization is in the cell membrane, nucleus, and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is known to be a component of intercellular desmosome junctions. Post-translational modifications have been described, including glycosylation. The gene encoding this protein is implicated in Palmoplantar keratoderma. Other names for this target antigen include DG1, DSG, EPKHE, EPKHIA, PPKS1, SPPK1, cadherin family member 4, and CDHF4. Gene orthologs have been identified in the mouse, rat, bovine and chimpanzee species. Over 80 citations in the literature describe the use of Desmoglein 1 antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.