Anti-EOMES antibodies are used in the immunodetection of the protein eomesodermin. In humans, the canonical protein has a reported length of 686 amino acid residues and a mass of 72.7 kDa. Its subcellular localization is in the nucleus. Up to 4 different isoforms have been reported for this protein. It is reported to be expressed in CD8+ T-cells. EOMES is known to function as a transcriptional activator playing a crucial role during development. The EOMES marker can be used to identify Upper Rhombic Lip Neurons, Amygdala Excitatory Neurons, TBet Low Liver NK Cells, Natural Killer (NK) Cells, and Pit Cells.* Synonyms for this target antigen include eomesodermin homolog, T-box brain protein 2, and TBR2. EOMES gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4