Anti-glutaminase 2 antibodies are used in the immunodetection of the protein encoded by the GLS2 gene. In humans, the canonical protein has a reported length of 602 amino acid residues and a mass of 66.3 kDa. Its subcellular localization is in the mitochondria. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be highly expressed in liver. A member of the Glutaminase protein family, it is known to play an important role in the regulation of glutamine catabolism. Other names for this target antigen include GLS, LGA, hLGA, glutaminase liver isoform, mitochondrial, L-glutamine amidohydrolase, and GA.