Anti-HHLA2 antibodies are used in the immunodetection of the protein HHLA2 member of B7 family. In humans, the canonical protein has a reported length of 414 amino acid residues and a mass of 46.9 kDa. Its subcellular localization is in the membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. It is notably expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include B7-H7, B7H7, B7y, HERV-H LTR-associating protein 2, HERV-H LTR-associating 2, and B7-H5.