TRNA methyltransferase 1, or, TRMT1, is a human gene. Other names include: tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase; TRM1; tRNA methyltransferase 1 homolog (S. cerevisiae). The encoded protein is an enzyme with an amino acid length of 659 and a mass of 72.2 kDa. TRNA methyltransferase 1 is a member of the Class I-like SAM-binding methyltransferase superfamily, Trm1 family. This gene shares homology with other species, including: Mouse.