Anti-Keratin 2 antibodies are used for the immunodetection of the protein encoded by the KRT2 gene. In humans, the canonical protein has a reported length of 639 amino acid residues and a mass of 65.4 kDa. Its subcellular localization is in the cytoplasm. A member of the Intermediate filament protein family, it is suspected to be contributes to terminal cornification. The gene encoding this protein is implicated in Ichthyosis bullosa of Siemens. Other names for this target antigen include K2e, KRT2A, KRT2E, KRTE, keratin, type II cytoskeletal 2 epidermal, cytokeratin-2e, epithelial keratin-2e, and CK-2e. Gene orthologs have been identified in the mouse, rat, bovine and chimpanzee species. Over 300 citations in the literature describe the use of Keratin 2 antibodies in research. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.