Anti-BCL11A antibodies are used in the immunodetection of the protein BCL11 transcription factor A. In humans, the canonical protein has a reported length of 835 amino acid residues and a mass of 91.2 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 5 different isoforms have been reported for this protein. It is notably expressed at high levels in the brain, spleen thymus, bone marrow and testis. BCL11A is known to be involved with the regulation of transcription. Post-translational modifications have been described, including sumoylation.
The BCL11A marker can be used to identify Lympho-Myeloid Progenitor (Lmpp) Cells.* Synonyms for this target antigen include DILOS, EVI9, HBFQTL5, SMARCM1, ZNF856, B-cell lymphoma/leukemia 11A, B cell CLL/lymphoma 11A, and CTIP1. BCL11A gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of BCL11A antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4