Anti-POU6F2 antibodies are used in the immunodetection of the protein POU class 6 homeobox 2. In humans, the canonical protein has a reported length of 691 amino acid residues and a mass of 73.3 kDa. Its subcellular localization is in the nucleus. Up to 2 different isoforms have been reported for this protein. A member of the POU transcription factor protein family, POU6F2 is a suspected transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. The POU6F2 marker can be used to identify Upper-Layer Intratelencephalic Neurons, Deep-Layer Intratelencephalic Neurons, Brain Splatter Neurons, and Ventral Excitatory Neurons.* Synonyms for this target antigen include WT5, WTSL, POU domain, class 6, transcription factor 2, Wilms tumor suppressor locus, retina-derived POU-domain factor-1, and RPF-1. POU6F2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4