Anti-ADAM10 antibodies are used in applications like western blot and immunofluorescence to target the protein encoded by the gene, ADAM metallopeptidase domain 10 (ADAM10) in humans. The canonical ADAM10 protein is 748 amino acids in length, 84.1 kDa in mass, and has a cytoplasmic, Golgi and membrane subcellular localization. ADAM10 functions in integrin binding and has endopeptidase activity. It plays a role in development, extracellular matrix organization, and signal transduction. Tissue-specific expression of ADAM10 has been observed in several tissues, including the brain, liver, spleen, fetal tissue, thymus, blood, bone and bone marrow. Post-translational modifications have been described, notably proteolytic cleavage and glycosylation. Synonyms for this protein include: AD10; AD18; CD156c; CDw156; HsT18717; MADM; RAK; kuz; a disintegrin and metalloprotease domain 10. Orthologs for ADAM10 have also been reported in other species, including mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken.