Anti-SLC14A1 antibodies are used in the immunodetection of the protein solute carrier family 14 member 1 (Kidd blood group). In humans, the canonical protein has a reported length of 389 amino acid residues and a mass of 42.5 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is notably expressed in erythrocytes. A member of the Urea transporter protein family, SLC14A1 is known to mediate the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes. Post-translational modifications have been described, including glycosylation.
The SLC14A1 marker can be used to identify Afferent Arteriole Endothelial Cells, Efferent Arteriole Endothelial Cells, Descending Vasa Recta Endothelial Cells, and Astrocytes.* Synonyms for this target antigen include HUT11A, HsT1341, JK, Jk(a), Jk(b), RACH1, RACH2, and HUT11. SLC14A1 gene orthologs have been reported in the mouse, rat, frog and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4