TRMT8, or Methyltransferase like 1, is a human gene encoded by METTL1. It may also be known as: Methyltransferase-like protein 1; guanine(46)-N(7))-methyltransferase; tRNA(m7G46)-methyltransferase; C12orf1; TRM8; YDL201w. The encoded protein is an enzyme with an amino acid length of 276 and a mass of 31.5 kDa. TRMT8 is a member of the Class I-like SAM-binding methyltransferase superfamily, TrmB family. Homologs of this gene exist in other organisms, including: Arabidopsis.