MAB206 Inhibits IL-6 Mediated Proliferation of TF-1 Bone Marrow Cells

October 25, 2019

Biologics
AbbVie
Research Scientist

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Company:

R&D Systems

Product Name:

Human/Primate IL-6 MAb (Clone 6708)

Catalog Number:

MAB206

Clone Number:

6708

In comparison to marketed anti-IL6 antibody therapy, Sirukumab, MAB206 inhibits bone marrow cell proliferation to a lesser extent.

Experimental Design and Results Summary

Applications

Cell Proliferation Assay

Sample

TF-1 cells

Primary Incubation

0.5ng/ml IL-6 stimulation

Blocking Agent

BSA

Secondary Incubation

10ug/ml antibody

Tertiary Incubation

N/A

Detection

Luminescence

Results Summary

MAB206 inhibits IL-6 mediated proliferation of human bone marrow cells.

DOI or PMID #

N/A

Additional Notes

N/A

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Summary

The Good

Product binds IL-6 and functionally inhibits bioactivity of ligand.

The Bad

Does not inhibit as well as Sirukumab.

The Bottom Line

The antibody MAB206 binds and functionally block IL-6 activity. It can be used to validate bone marrow proliferation assays.

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