The Good
Works every time with no optimization needed. Follow the manufacturer's instructions and also pair it with a good anti-rabbit HRP-linked secondary Ab (CST: 7074) and you will have no issues.
The Bad
Cannot think of anything.
The Bottom Line
This is the go-to antibody for detecting PTEN expression by Western blotting. No optimization is required; just use as suggested by the manufacturer, and you'll have great-looking PTEN Western blots.