383-CD (CD14) Prevents LPS Binding to TLR4

April 16, 2019

Discovery
Pharma Company
Research Scientist

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Company:

R&D Systems

Product Name:

Recombinant Human CD14 Protein

Catalog Number:

383-CD

Clone Number:

 

 

Protein interaction analysis via SPR indicated that 383-CD (CD14) does not bind TLR4. However, when 383-CD (CD14) is mixed with LPS, LPS no longer binds TLR4.

Experimental Design and Results Summary

Applications

Biacore

Sample

Human

Primary Incubation

500nM

Blocking Agent

N/A

Secondary Incubation

N/A

Tertiary Incubation

N/A

Detection

SPR

Results Summary

Binding curves were generated.

DOI or PMID #

N/A

Additional Notes

N/A

Image Gallery

Summary

The Good

Product binds LPS as expected.

The Bad

Expensive

The Bottom Line

The protein shows desired binding interactions and neutralizes TLR4 interactions with LPS.

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