Niflumic Acid Increases Non-Selective Cationic Current in Cardiomyocytes

Medical University of Graz
Department of Cardiology
Postdoctoral Researcher

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Company:

Tocris Bioscience

Product Name:

Niflumic acid

Catalog Number:

4112/50

Non-selective cationic current was measured in guinea pig cardiomyocytes before and after superfusion with 100 µM niflumic acid for 10 min. Compared to time matched rundown, niflumic acid significantly increased inward as well as outward non-selective cationic current in cardiomyocytes.

Experimental Design and Results Summary

Application

Cardiac electrophysiology

Starting Material

Primary ventricular cardiomyocytes

Protocol Overview

Non-selective cationic current was measured in guinea pig cardiomyocytes before and after superfusion with 100 µM niflumic acid for 10 min.

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Results Summary

Compared to time matched rundown, niflumic acid significantly increased inward as well as outward non-selective cationic current in cardiomyocytes.

DOI or PMID #

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Summary

The Good

Works as expected

The Bad

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The Bottom Line

Niflumic acid increases non-selective cationic current in cardiomyocytes

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