Elucidation of the Cellular and Molecular Features of the TME Underlying Immune Escape and IO Failure
Alexander Bagaev, Ph.D.
Tuesday, May 2, 2023
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Chapters
BostonGene-Alexander Bagaev
A New Era for Personalized Medicine
We can Measure Tumor at an Unprecedented Level of Detail
Deconstructing the tumor microenvironment (TME)
Precise Reconstruction of the TME from Bulk RNA-seq
Kassandra' Cell Deconvolution Allows for Identifying Biomarkers of Response to the Therapy
Compiling the Tumor Portrait from Integrated WES and RNA-seq
Conserved TME Types Predict Response to Immunotherapy
Tumor Portrait Types Correlate with Efficacy of Immunotherapy in Melanoma, Gastric Cancer, Bladder Cancer, Lung Cancer
The Added Value of TME Analytics
End-to-End Automated Workflow Solutions with Agilent Automation/Reagents
Performance Characteristics of RNA-seq from FFPE
Most Comprehensive Bioinformatic Pipeline is unmatched in the industry
New Generation of Clinical Reporting
BostonGene Dataverse for Biomarker Development
Identifying Tumor Immune Escape Mechanism
TME Subtype Expansion with Analysis of 37,596 Patients: Classifying Types of Tumor Immune Escape
Immune Escape Subtypes
Patient Selection into Combinational Trials Guided with Comprehensive Cancer Profiling
Comprehensive Disease Profiling Through Cutting-Edge Research
Conclusions
Solutions for Patient Stratification and Research
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