There is growing interest in understanding how proteolysis-targeting chimeric molecules (PROTACs) and molecular glues can effectively degrade proteins that are important targets for drug discovery and therapeutic intervention. However, designing, characterizing, and optimizing these molecules can be challenging.
This Bench Tips webinar brings together scientists who are keen to share their knowledge and expertise using various biochemical, cell-based and computational techniques to find the right degraders for the drug targets to enable their targeted degradation. Their short presentations will be followed by a live Q&A session for open discussion and sharing of best practices and technical know-how.
In this webinar, you will hear about:
- How to rationally design PROTAC degraders and molecular glues
- How to pick the right techniques for structural and mechanistic studies
- Which biochemical and cell-based assays to use for measuring degradation
- What are some of the common challenges—from sample prep to data analysis
Researchers interested in the following should attend:
- Proteomic assays and screening
- Chemical biology
- Medicinal chemistry
- Target identification
- Compound optimization
- Computational design and screening