Efficient Sample Preparation with Covaris AFA
®
Technology Enhances Confidence in Illumina
®
TruSight
™
Oncology 500 Assay
Eugenio Daviso, Ph.D.
Tuesday, November 8, 2022
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Chapters
Introduction
Agenda
Evolution in Sample Prep – Enabled by Adaptive Focused Acoustics
®
Technology
Global Leader in Pre-Analytical Sample Preparation
The Covaris Solution for RNA and DNA Extraction from FFPE
truXTRAC® FFPE total NA Auto 96 Extraction Performance
RNA Yield and Purity
RNA Quality Metrics
DNA Yield and Purity
DNA Quality Metrics
A New Method for Determining DNA Quality from FFPE (I)
A New Method for Determining DNA Quality from FFPE (II)
Opportunities and Challenges of NGS in Oncology
Collaborative Solution for Development of NGS Clinical Oncology Research
OmniSeq – Labcorp Oncology Comprehensive Genomic Profiling
Tumor Profiling Workflow – Fit-for-Purpose Delivery
Comprehensive Genomic and Immune Profiling Supports Precision Medicine
TruSight Oncology 500 – Enabling Comprehensive Genomic Profiling of Tumor Samples
TruSight Oncology 500 Sequencing Performance with truXTRAC FFPE total NA Auto 96 Chemistry
Sample QC metrics, TSO500 DNA – Median of Absolute Deviations and Bin Count
Sample QC metrics, TSO500 DNA – Exon Coverage and Insert Size
Sample QC metrics, TSO500 DNA – Usable Microsatellite Instability Sites
Sample QC metrics, TSO500 RNA
Acknowledgements
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