Multimodal and multiscale imaging of CAR T cells in a pancreatic adenocarcinoma xenograft model reveals negative effects of local IL-2 administration
Rita Pfeifer, Ph.D.
Monday, April 18, 2022
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Chapters
Introduction
Presentation: Rita Pfeifer
FDA Approved CAR T cell Therapy: Blood vs. Solid
A multimodal imaging workflow for monitoring CAR T cell therapy against solid tumor from whole-body to single-cell level
System Overview
CAR T cell Tracking by BLT: Transgene Design
In vivo study outline
Bioluminescent Imaging of Luc+ CAR T cells
Light Sheet 3D Microscopy for Spatial Resolution of CAR T-Tumor Cell Interactions
3D Animation Demo
MACSima™ Imaging Platform
2D MICS Data Correlates With 3D UM Data
Intratumoral EGFR CAR T cells exhibit higher levels of exhaustion
Intratumoral EGFR CAR T cells exhibit higher levels of exhaustion
Conclusions
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