While there is growing interest in understanding how proteolysis-targeting chimeric molecules (PROTACs) can effectively degrade proteins that are important targets for drug discovery and therapeutic intervention, there are many intricacies involved in designing, characterizing, and working with PROTACs.
This Bench Tips webinar brings together a group of early-career scientists who are using various biochemical, cell-based, and computational techniques to find the right targets and PROTAC molecules for targeted degradation. They are keen to share their knowledge and expertise in the preparation of cells and reagents, choosing the right assays and platforms, and other troubleshooting tips. Their short presentations will be followed by a live Q&A session for open discussion and sharing of best practices and technical know-how.
You will learn about:
- How to rationally design PROTAC degraders
- How to pick the right targets for degradation
- How to study PROTAC-induced ternary complex formation
- How linker design can affect PROTAC stability and efficacy
- Which biochemical and cell-based assays to use for studying degradation
- New generation of degrader molecules being developed (photoPROTACs, TRAFTACs)
- Case studies describing how PROTACs are being used for successful degradation
Researchers interested in the following should attend:
- Protein degradation
- Proteomics
- Chemical biology
- Target identification
- Hit-to-lead optimization
- Biochemical and cell-based screening
- Computational drug design