A Unified Atlas of CD8 T Cell Dysfunctional States in Cancer and Infection

CD8 T cells play an essential role in defense against viral and bacterial infections and in tumor immunity. However, it’s difficult to identify the drivers of T cell loss of functionality in disease due to the heterogeneity of CD8 T cell states described across experimental and clinical settings. 

In this webinar, Yuri Pritykin, PhD, Assistant Professor of computer science at the Lewis-Sigler Institute for Integrative Genomics, Princeton University, will describe an integrated approach to model T cell differentiation trajectories toward dysfunction—and identify underlying transcriptional drivers—leveraging over 300 ATAC-seq (Assay for Transposase-Accessible Chromatin) and RNA-seq datasets from 12 studies of CD8 T cells in cancer and infection.

In this webinar you’ll learn:

• How single-cell ATAC-seq and single-cell RNA-seq identified state-specific drivers in acute and chronic viral infection
• When and how functional and dysfunctional T cells diverge from each other, indicated by the emergence of similar TCF1+ progenitor-like populations at an early branch point
• The value of a multiomic atlas of CD8 T cell states to facilitate mechanistic studies of T cell immunity and translational efforts 

Who should attend:

• Immunologists
• Oncologists
• Infectious disease researchers