Automated chemical storage and high-throughput compound synthesis using the Hamilton Verso and Microlab VANTAGE Liquid Handling System
Derrick Miyao
Friday, March 2, 2018
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Chapters
Introduction
Integrated storage (Verso) and chemical synthesis (Vantage)
Verso
MICROLAB Vantage
Research Evolution
Lead Optimization: Iterative Design Cycle
Optimize Cycle Time
Reagent Management
Compound Management: Matrical Matristore
Reaction Ready Reagents in solution
Concerns with storing chemical solutions in the Matristore
10+ years of storing reagents in solution
Standardizing bulk storage containers
Build a chemistry specific automation platform for storage and synthesis
Requirements for automated storage and synthesis
Vantage/Verso
Convergent Optimization Retrosynthesis
Convergent Synthesis
Convergent Optimization
Bottom region
Assemble virtual compounds
One assay for compound synthesis
Manual Chemistry Process
Automated Chemistry Process
Vantage/Verso integration results
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