Clonal Evolution and Changes of Gene Mutations in Two AML Patients Detected with Mission Bio Single-cell DNA Sequencing
Liwen Xu, Ph.D.
Thursday, December 7, 2017
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Chapters
Introduction
Clonal Evolution and Changes of Gene Mutations in Two AML Patients Detected with Mission Bio Single-cell DNA Sequencing
Workflow of Tapestri Single-cell DNA-Seq
Clinical Information of Stanford Clinical Samples
Quality Control of Single-cell DNA Sequencing
Comparison of VAF between the Bulk Stanford NGS Myeloid Panel and Single-cell NGS AML Panel
SNV Hierarchical Clustering in PBMCs of Patient 1
Clonal Evolution in PBMCs of Patient 1
Changes in Chimerism and AML Status of Patient 1
Cell Clustering in PBMCs of Patient 1
Summary of Patient 1
SNV Hierarchical Clustering in PBMCs of Patient 2
Clonal Evolution in PBMCs of Patient 2
Changes in Chimerism and AML Status of Patient 2
Cell Clustering in PBMCs of Patient 2
Summary of Patient 2
Model of AML Relapse in BMT Patients
Summary
Acknowledgement
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