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The in vitro use of iPSC (induced pluripotent stem cells)-derived cell types allows the unparalleled ability to model human disease and identify novel ...
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Accumulation of cytosolic protein aggregates is a hallmark of neurodegenerative diseases, including Alzheimer’s (AD), Parkinson’s (PD), Huntington’s (HD), and ...
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During the past decade, induced pluripotent stem cell (iPSC) technology has become an attractive in vitro model to generate clinically relevant cells, including...
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Aggresomes are inclusion bodies that form when the ubiquitin–proteasome machinery is overwhelmed with aggregation-prone proteins. Typically, an aggresome forms in response to some cellular stress, such as hyperthermia, viral infection, or exposure to reactive oxygen species. ... More »
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