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Using CRISPR Interference to Screen for Cancer Drug Resistance

In this app note, a CRISPRi platform is used to probe development of resistance to the BRAF inhibitor vemurafenib in cancer. The authors hypothesize that a CRISPRi system would allow a subset of cells in the population to become resistant to vemurafenib treatment due to decreased gene transcription. Download now

Research News

Identifying Functional Phosphosites with Machine Learning
New Tool Improves Understanding of Protein Function and Design
Metformin’s Diverse Benefits Linked to GDF-15
New Proteomics Technique Gives Insight into Cellular Stress
Enzymes Contributing to Insecticide Resistance in Mosquitos
Library of Fungi-Derived Bioactive Compounds Developed

Featured Articles

Elucidating the Dark Metabolome

Novel tools are shedding light on potential treasure trove... Read more

Responding to Biosafety Cabinet Alarms

Advance preparation and training are key... Read more

In Vivo, In Vitro, or In Silico: Tips for Choosing a Model System

Evaluating tradeoffs to find the optimal model for your research... Read more

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Product Reviews

Great Antibody for Assessing Total Ribosomal S6 Protein for Immunoblotting

Great great antibody critical for assessing total S6 levels. Read more

Recommended Anti-Hemoglobin Antibody

Good staining of Hemoglobin at vascular leakage sites. Read more

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Review a product on Biocompare and earn an Amazon gift card

When you review a product used in your life science research, your shared experience can help other scientists make better-informed decisions. You will earn an Amazon gift code per accepted review. Start your review today! Read more

Featured Products

MultiFlo FX Automated Washer and Multi-Mode Dispenser

MultiFlo™ FX is an automated multi-mode reagent dispenser for 6- to 1536-well microplates offering BioTek’s unique Parallel Dispense™ technology. Up to four independent reagents can be dispensed in ... Read more

Epoch™ 2 Microplate Spectrophotometer

Epoch™ 2 Microplate Spectrophotometer offers excellent performance for UV-Vis measurements in 6- to 384-well microplates, cuvettes and in micro-volume samples with the available Take3™ Micro-Volume ... Read more

Promotion

Challenge25 - Celebrating our Anniversary Year

In order to celebrate our 25th anniversary, we wanted to start to make our mission for ensuring a better and more healthy world become even more visible. This has resulted in us challenging ourselves and during the course of 2019 we announced five different categories for 25 actions. ... Read more

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Webinar

Adventures with Imaging Flow Cytometry: Aging Cells, Giant Viruses and Golgi Fragmentation

In this webinar we will describe three recent applications for imaging flow cytometry (IFC), a ... Watch now

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Adventures with Imaging Flow Cytometry: Aging Cells, Giant Viruses and Golgi Fragmentation

Events

SLAS 2020

SLAS2020 International Conference and Exhibition brings together thousands of scientists, researchers, academics and government professionals looking to leverage life sciences discovery and technology to transform research and build their peer network. The scientific program is centered around 10 ... Read more

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395 Oyster Point Blvd, Suite 300
South San Francisco, CA 94080 USA

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