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HERG-Lite® – hERG Channel Trafficking Assay
High Throughput, Non-Electrophysiological screening service for hERG risk
Identify compounds that produce hERG risk by trafficking inhibition. HERG-Lite® is a unique, rapid and cost-effective assay that monitors hERG expression at the cell surface. Trafficking-associated decreases in hERG activity occur hours after exposure to compound, but are as important to assessing risk as direct block. HERG-Lite® identifies hERG trafficking inhibitors by exposing wild-type (WT) hERG to drug overnight, and hERG channel blockers by measuring rescue of a trafficking-defective mutant hERG (SM) cell line. more »
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