Fig 1: Serum levels of ICAM-1, VEGF and NO in septic rats treated with recombinant human NRG-1. n=6. Data are presented as the mean ± standard deviation. *P<0.05 vs. sham group; #P<0.05 vs. LPS group; $P<0.05 vs. 24 h group. ICAM-1, intercellular cell adhesion molecule-1; VEGF, vascular endothelial growth factor; NO, nitric oxide; LPS, lipopolysaccharide; NRG-1, neuregulin-1.
Fig 2: Quinacrine attenuated cisplatin-induced dysregulation of SIRT-1, ICAM-1 and TNF-a. Effect of quinacrine administration (10 mg/kg/rat/ day: i.p) against cisplatin-induced nephrotoxicity in rats on (A) renal sirtuin-1 (SIRT-1) concentration (n = 7–8), (B) renal intercellular adhesion molecule-1 (ICAM-1) concentration (n = 7–8), (C) renal tumor necrosis factor-a (TNF-a) concentration (n = 7–8) and (D) % area of TNF-a immunostaining (n = 6). (E) Microscopic pictures of immunostained renal sections against TNF-a showing negative expression in normal group and strong positive tubular expression appears in affected areas in renal sections from cisplatin group. The positive brown tubular expression decreased in renal sections from cisplatin + quinacrine group. (Arrowheads point to positive brown reaction.) High magnification X:400 bar 25. *: p < 0.05; **: p < 0.01 and *** p < 0.001. Data are expressed as mean ± SEM.
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