Fig 1: A–C The systolic blood pressure (A), diastolic blood pressure (B), and mean arterial pressure (C) of CM and CA rats at different time points. D–F The meta2d_pvalue (D), mata2d_AMP (E), and meta2d_phase (F) of the blood pressure in the CM and CA rats at six time points during the 24-h cycle, respectively. *p < 0.05, **p < 0.01, ***p < 0.001. Weights of rats in the two groups after (G) and before (H) the modeling. Serum LDH (I), BNP (J), CK-MB (K), ANGII (08:00) (L), and ANGII (20:00) (M) of the two groups of rats. *p < 0.05, **p < 0.01, ***p < 0.001 (two-sample t-test). Abbreviations: ANGII, angiotensin II; BNP, brain natriuretic peptide; CK-MB, creatine kinase-MB; LDH, lactate dehydrogenase; SBP, systolic blood pressure; DBP, diastolic blood pressure; MBP, mean blood pressure