Fig 1: Enrichment and network analyses of proteins linked to small HDL-4-Apo A-2. (A) Significantly enriched biological processes related to the nine proteins associated independently with HDL-4-Apo A-2 in linear regression models. Pathways are in order of the corresponding fold enrichment. Highlighted in red are those biological process related to fibrinolysis. (B) Network analysis of nine proteins identified based on second order partial Spearman’s rank correlation coefficients (all p<0.0001). Highlighted in grey are proteins, which function is related to regulation of fibrinolysis, and in red is HDL-4-Apo A-2. The width of connection lines is graded according to the strength of correlation. The dotted connection line indicates an inverse relation. A2AP, alpha-2-antiplasmin; Apo, apolipoprotein; A2SG, alpha-2-HS-glycoprotein; CNDP1, carnosine dipeptidase 1; FXI, factor XI; GHR, growth hormone receptor; HDL, high-density lipoprotein; NRP1, neuropilin-1; PKK, prekallikrein.