Fig 1: Serum concentrations of hs-CRP, LTB4, PGD2, MCT, D-dimer and HIS in the CSU (n = 56) and healthy control (n = 13) groups. Differences between groups were assessed using Mann–Whitney U-tests; experiments were repeated three times.
Fig 2: Schematic diagrams showing the coefficients relating inflammation markers, compromised LVEF with adverse cardiovascular events and the mediation effect of translocation z-score. a Association between CD14++CD16+ monocytes and MACE mediated by translocation z-score. b Association between compromised LVEF (derived from Youden index for MACE) and MACE mediated by translocation z-score. c Association between hs-CRP and MACE mediated by translocation z-score. ß indicates coefficients in regression analysis; TE, total effect; ADE, average direct effect; ACME, average causal mediation effect; CI, confidence interval; MACE, major adverse cardiovascular events; LVEF, left ventricular ejection fraction; hs-CRP, high-sensitivity C-reactive protein. *P < 0.05, **P < 0.01
Fig 3: Expression of inflammatory factors and myocardial enzymes in patients.A: Mean serum IL-1ß expression level for each group of patients. B: Mean serum TNF-a expression level for each group of patients. C: Mean serum hs-CRP expression level for each group of patients.D: Mean serum NT-pro-BNP expression level for each group of patients. E: Mean serum cTnI expression level for each group of patients. F: Mean serum CK-MB expression level for each group of patients. **P<0.01.
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