Fig 1: A : JAK/STAT-IFNAR and JAK/STAT-IFN-? receptor signaling pathway. B : Western blot analysis demonstrated the relative expressions of active JAK1, Phospho-JAK1 (p Y1022+Y1023), JAK2, Phospho-JAK2 (p Tyr1007, Tyr1008), Phospho-STAT1 [p Tyr701], STAT3, Phospho-STAT3 (p Tyr705), SOCS7 and ß-actin in the 50, 100, and 200 nM ruxolitinib treated and untreated (control=1) U87 spheroids. CM : cell membrane, NM : nuclear membrane, JAK/STAT : Janus kinase-signal transducer and activator of transcription, IFNAR : interferon alpha receptor, IFN : interferon, SOCS : the suppressor of cytokine signalling.