IL-17/IL-17A Antibody MAB721-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-17/IL-17A Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMAB721-100
Quantity100 ug (also 500 ug, 25 ug)
ApplicationsWestern Blot, ELISA Capture (Matched Antibody Pair)
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ReactivityMouse
TargetIL-17/IL-17A
IsotypeIgG2a
Clone50101
HostRat
ImmunogenE. coli-derived recombinant mouse IL-17, Thr22-Ala158, Accession # Q62386
NCBI Full Gene Nameinterleukin 17A
NCBI Gene AliasesCtla-8, IL-17A, Il17, Ctla8, IL-17
ClonalityMonoclonal
PurityProtein A or G purified from hybridoma culture supernatant
Brand/TrademarkR&D Systems, a Bio-Techne Brand
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

Specificity: Detects mouse IL-17 in ELISAs and Western blots. In direct ELISAs, 100% reactivity with recombinant mouse (rm) IL-17A/IL-17F heterodimer, 50% cross-reactivity with recombinant human IL-17, and 25% cross-reactivity with recombinant canine IL-17 is observed. No cross-reactivity with rmIL-17B, rmIL-17C, rmIL-17D, rmIL-17E, or rmIL-17F is observed. In Western blots, cross-reactivity with recombinant rat IL-17A is observed

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Depletion of Foxp3(+) regulatory T cells augments CD4(+) T cell immune responses in atherosclerosis-prone hypercholesterolemic miceHeliyonJuly 1, 2022Kasahara K, Sasaki N, Amin HZ, Tanaka T, Horibe S, Yamashita T, Hirata KI, Rikitake Y.

(2) Interleukin-17 affects synaptic plasticity and cognition in an experimental model of multiple sclerosisCell reportsDecember 7, 2021Di Filippo M, Mancini A, Bellingacci L, Gaetani L, Mazzocchetti P, Zelante T, La Barbera L, De Luca A, Tantucci M, Tozzi A, et al.

(3) Interferon-gamma regulates inflammatory cell death by targeting necroptosis in experimental autoimmune arthritisScientific reportsAugust 31, 2017Lee SH, Kwon JY, Kim SY, Jung K, Cho ML.

(4) The Major Histocompatibility Complex Class III Haplotype Ltab-Ncr3 Regulates Adjuvant-Induced but Not Antigen-Induced AutoimmunityThe American journal of pathologyMay 1, 2017Yau ACY, Tuncel J, Holmdahl R.

(5) MHC class II alleles associated with Th1 rather than Th17 type immunity drive the onset of early arthritis in a rat model of rheumatoid arthritisEuropean journal of immunologyMarch 1, 2017Tuncel J, Haag S, Holmdahl R.

(6) IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacologyJanuary 1, 2017Lv R, Zhao J, Lei M, Xiao D, Yu Y, Xie J.

(7) Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacyNature communicationsDecember 22, 2016Griffiths KL, Ahmed M, Das S, Gopal R, Horne W, Connell TD, Moynihan KD, Kolls JK, Irvine DJ, Artyomov MN, et al.

(8) Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritisScientific reportsJune 1, 2016Lim JY, Im KI, Lee ES, Kim N, Nam YS, Jeon YW, Cho SG.

(9) Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challengeMucosal immunologySeptember 1, 2015Monin L, Griffiths KL, Slight S, Lin Y, Rangel-Moreno J, Khader SA.

(10) Positional identification of RT1-B (HLA-DQ) as susceptibility locus for autoimmune arthritisJournal of immunology (Baltimore, Md. : 1950)March 15, 2015Haag S, Tuncel J, Thordardottir S, Mason DE, Yau AC, Dobritzsch D, Bäcklund J, Peters EC, Holmdahl R.

(11) CD8⁺ cells regulate the T helper-17 response in an experimental murine model of Sjögren syndromeMucosal immunologyMarch 1, 2014Zhang X, Schaumburg CS, Coursey TG, Siemasko KF, Volpe EA, Gandhi NB, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC, et al.

(12) Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenasePloS oneJanuary 1, 2013Lee J, Lee J, Park MK, Lim MA, Park EM, Kim EK, Yang EJ, Lee SY, Jhun JY, Park SH, et al.

(13) CCL25 induces α₄β₇ integrin-dependent migration of IL-17⁺ γδ T lymphocytes during an allergic reactionEuropean journal of immunologyMay 1, 2012Costa MF, Bornstein VU, Candéa AL, Henriques-Pons A, Henriques MG, Penido C.

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(15) Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma productionProceedings of the National Academy of Sciences of the United States of AmericaApril 7, 2009Lemos HP, Grespan R, Vieira SM, Cunha TM, Verri WA Jr, Fernandes KS, Souto FO, McInnes IB, Ferreira SH, Liew FY, et al.

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(17) The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23-->IL-17 axisJournal of immunology (Baltimore, Md. : 1950)June 15, 2007Sheibanie AF, Yen JH, Khayrullina T, Emig F, Zhang M, Tuma R, Ganea D.

(18) IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infectionJournal of immunology (Baltimore, Md. : 1950)October 1, 2006Lockhart E, Green AM, Flynn JL.

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IL-17/IL-17A Antibody

IL-17/IL-17A Antibody

IL-17/IL-17A Antibody

IL-17/IL-17A Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (20)

Reviews

IL-17/IL-17A Antibody from R&D Systems, a Bio-Techne Brand

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