IL-17/IL-17A Antibody MAB421-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-17/IL-17A Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMAB421-100
Quantity100 ug (also 500 ug, 25 ug)
ApplicationsWestern Blot, Neutralization
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ReactivityMouse
TargetIL-17/IL-17A
IsotypeIgG2a
Clone50104
HostRat
ImmunogenE. coli-derived recombinant mouse IL-17, Thr22-Ala158, Accession # Q62386
NCBI Full Gene Nameinterleukin 17A
NCBI Gene AliasesCtla-8, IL-17A, Il17, Ctla8, IL-17
ClonalityMonoclonal
PurityProtein A or G purified from hybridoma culture supernatant
Brand/TrademarkR&D Systems, a Bio-Techne Brand
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

Specificity: Detects mouse IL-17 in direct ELISAs and Western blots. In direct ELISAs, 100% reactivity with recombinant rat IL-17A and approximately 40% reactivity with recombinant mouse (rm) IL-17A/IL-17F heterodimer is observed. No cross-reactivity with recombinant human IL-17, recombinant canine IL-17, rmIL-17B, rmIL-17C, rmIL-17D, rmIL-17E, or rmIL-17F is observed

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's diseaseNature communicationsMarch 24, 2023Choi BJ, Park MH, Park KH, Han WH, Yoon HJ, Jung HY, Hong JY, Chowdhury MR, Kim KY, Lee J, et al.

(2) Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficitsScience advancesMay 6, 2022Yu D, Li T, Delpech JC, Zhu B, Kishore P, Koshi T, Luo R, Pratt KJB, Popova G, Nowakowski TJ, et al.

(3) Blocking the interaction between interleukin-17A and endoplasmic reticulum stress in macrophage attenuates retinal neovascularization in oxygen-induced retinopathyCell & bioscienceMay 1, 2021Wang Y, Gao S, Gao S, Li N, Xie B, Shen X.

(4) T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitisNature communicationsOctober 26, 2020Napier RJ, Lee EJ, Davey MP, Vance EE, Furtado JM, Snow PE, Samson KA, Lashley SJ, Brown BR, Horai R, et al.

(5) Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infectionJCI insightMay 30, 2019Zychlinsky Scharff A, Rousseau M, Lacerda Mariano L, Canton T, Consiglio CR, Albert ML, Fontes M, Duffy D, Ingersoll MA.

(6) Endogenous IL-17A mediated neutrophil infiltration by promoting chemokines expression during chlamydial lung infectionMicrobial pathogenesisApril 1, 2019Qiao S, Zhang H, Zha X, Niu W, Liang J, Pang G, Tang Y, Liu T, Zhao H, Wang Y, et al.

(7) B Cells Produce the Tissue-Protective Protein RELMα during Helminth Infection, which Inhibits IL-17 Expression and Limits EmphysemaCell reportsDecember 4, 2018Chen F, Wu W, Jin L, Millman A, Palma M, El-Naccache DW, Lothstein KE, Dong C, Edelblum KL, Gause WC.

(8) Galectin-9 Is Critical for Mucosal Adaptive Immunity through the T Helper 17-IgA AxisThe American journal of pathologyMay 1, 2018Liang CC, Li CS, Weng IC, Chen HY, Lu HH, Huang CC, Liu FT.

(9) Estrogen Deficiency Promotes Cerebral Aneurysm Rupture by Upregulation of Th17 Cells and Interleukin-17A Which Downregulates E-CadherinJournal of the American Heart AssociationApril 13, 2018Hoh BL, Rojas K, Lin L, Fazal HZ, Hourani S, Nowicki KW, Schneider MB, Hosaka K.

(10) Interferon induced protein 35 exacerbates H5N1 influenza disease through the expression of IL-12p40 homodimerPLoS pathogensApril 1, 2018Gounder AP, Yokoyama CC, Jarjour NN, Bricker TL, Edelson BT, Boon ACM.

(11) Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritisCell death & diseaseMarch 14, 2018Lee CJ, Moon SJ, Jeong JH, Lee S, Lee MH, Yoo SM, Lee HS, Kang HC, Lee JY, Lee WS, et al.

(12) IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion InjuryJournal of immunology (Baltimore, Md. : 1950)October 15, 2017Geha M, Tsokos MG, Bosse RE, Sannikova T, Iwakura Y, Dalle Lucca JJ, De Waal Malefyt R, Tsokos GC.

(13) IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E₂ during Lung Fungal InfectionJournal of immunology (Baltimore, Md. : 1950)September 15, 2017Garth JM, Reeder KM, Godwin MS, Mackel JJ, Dunaway CW, Blackburn JP, Steele C.

(14) Galectin-1-Driven Tolerogenic Programs Aggravate Yersinia enterocolitica Infection by Repressing Antibacterial ImmunityJournal of immunology (Baltimore, Md. : 1950)August 15, 2017Davicino RC, Méndez-Huergo SP, Eliçabe RJ, Stupirski JC, Autenrieth I, Di Genaro MS, Rabinovich GA.

(15) IL-35 induces N2 phenotype of neutrophils to promote tumor growthOncotargetMay 16, 2017Zou JM, Qin J, Li YC, Wang Y, Li D, Shu Y, Luo C, Wang SS, Chi G, Guo F, et al.

(16) Spirulina lipopolysaccharides inhibit tumor growth in a Toll-like receptor 4-dependent manner by altering the cytokine milieu from interleukin-17/interleukin-23 to interferon-γOncology reportsFebruary 1, 2017Okuyama H, Tominaga A, Fukuoka S, Taguchi T, Kusumoto Y, Ono S.

(17) IL-17A exacerbates diabetic retinopathy by impairing Müller cell function via Act1 signalingExperimental & molecular medicineDecember 16, 2016Qiu AW, Bian Z, Mao PA, Liu QH.

(18) IL-17 Augments B Cell Activation in Ocular Surface AutoimmunityJournal of immunology (Baltimore, Md. : 1950)November 1, 2016Subbarayal B, Chauhan SK, Di Zazzo A, Dana R.

(19) Interleukin-27 (IL-27) Mediates Susceptibility to Visceral Leishmaniasis by Suppressing the IL-17-Neutrophil ResponseInfection and immunityAugust 1, 2016Quirino GFS, Nascimento MSL, Davoli-Ferreira M, Sacramento LA, Lima MHF, Almeida RP, Carregaro V, Silva JS.

(20) Seminal plasma induces inflammation in the uterus through the γδ T/IL-17 pathwayScientific reportsApril 25, 2016Song ZH, Li ZY, Li DD, Fang WN, Liu HY, Yang DD, Meng CY, Yang Y, Peng JP.

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IL-17/IL-17A Antibody

IL-17/IL-17A Antibody

IL-17/IL-17A Antibody

IL-17/IL-17A Antibody

IL-17/IL-17A Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (89)

Reviews

IL-17/IL-17A Antibody from R&D Systems, a Bio-Techne Brand

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