IL-4R alpha Antibody MAB230-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-4R alpha Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMAB230-100
Quantity100 ug (also 500 ug, 25 ug)
ApplicationsWestern Blot, Flow Cytometry, Immunohistochemistry, Neutralization, Immunocytochemistry, CyTOF-ready
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ReactivityHuman
TargetIL-4R alpha
IsotypeIgG2a
Clone25463
HostMouse
ImmunogenS. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-4 R, Gly24-His232, Accession # P24394
NCBI Full Gene Nameinterleukin 4 receptor
NCBI Gene AliasesCD124, IL-4RA, IL4RA
ClonalityMonoclonal
Brand/TrademarkR&D Systems, a Bio-Techne Brand
PurityProtein A or G purified from ascites
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

Specificity: Detects human IL-4 R alpha in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-9 R, recombinant mouse IL-4 R, rhIL-5 R alpha, rhIL-5 R beta, rhIL-13 R alpha 1, or rhIL-13 R alpha 2 is observed

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expressionJCI insightJune 22, 2022Fang F, Cao W, Mu Y, Okuyama H, Li L, Qiu J, Weyand CM, Goronzy JJ.

(2) Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19PLoS pathogensJanuary 1, 2022Mairpady Shambat S, Gómez-Mejia A, Schweizer TA, Huemer M, Chang CC, Acevedo C, Bergada-Pijuan J, Vulin C, Hofmaenner DA, Scheier TC, et al.IFNGR1 (1 μg/ml, MAB6731-SP, R&D systems), TNF R1 (1 μg/ml, 55R-170, ThermoFisher) and IL4 Rα (1 μg/ml, MAB230-100, R&D systems) were added to the cells in RPMI. IgG1 (Clone # 11711, R&D systems) and IgG2a (clone Clone

(3) The IL-4/IL-13 signaling axis promotes prostatic fibrosisPloS oneJanuary 1, 2022D'Arcy Q, Gharaee-Kermani M, Zhilin-Roth A, Macoska JA.

(4) Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injuryScience advancesMarch 1, 2020Karhausen J, Choi HW, Maddipati KR, Mathew JP, Ma Q, Boulaftali Y, Lee RH, Bergmeier W, Abraham SN.

(5) Potentiation of IL-4 Signaling by Retinoic Acid in Intestinal Epithelial Cells and Macrophages-Mechanisms and TargetsFrontiers in immunologyJanuary 1, 2020Chen C, Smith AD, Cheung L, Pham Q, Urban JF Jr, Dawson HD.antibody [Santa Cruz (SC-48338), 1:200)] anti-human IL-4R monoclonal antibody 25463 (R & D Systems # MAB230100 2 1:500) and rabbit anti-GAPDH (Cell Signaling # 21185, 1:1000-1:2000) overnight at 4°C. Blots were

(6) Ex vivo physiological compression of human osteoarthritis cartilage modulates cellular and matrix componentsPloS oneJanuary 1, 2019Dolzani P, Assirelli E, Pulsatelli L, Meliconi R, Mariani E, Neri S.

(7) Allergen-specific IgG antibody signaling through FcγRIIb promotes food toleranceThe Journal of allergy and clinical immunologyJanuary 1, 2018Burton OT, Tamayo JM, Stranks AJ, Koleoglou KJ, Oettgen HC.

(8) IL4 Primes the Dynamics of Breast Cancer Progression via DUSP4 InhibitionCancer researchJune 15, 2017Gaggianesi M, Turdo A, Chinnici A, Lipari E, Apuzzo T, Benfante A, Sperduti I, Di Franco S, Meraviglia S, Lo Presti E, et al.

(9) Absence of a role for interleukin-13 in inflammatory bowel diseaseEuropean journal of immunologyFebruary 1, 2014Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque SS, Ghanbari A, Joe-Njoku I, Giuffrida P, et al.

(10) Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4Journal of immunology (Baltimore, Md. : 1950)January 1, 2014Volonté A, Di Tomaso T, Spinelli M, Todaro M, Sanvito F, Albarello L, Bissolati M, Ghirardelli L, Orsenigo E, Ferrone S, et al.

(11) IL-4 and IL-13 differentially regulate TLR-induced eosinophil-basophil differentiation of cord blood CD34+ progenitor cellsPloS oneJanuary 1, 2014Reece P, Gauvreau GM, Sehmi R, Denburg JA.

(12) Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1β-stimulated production of chemokines and matrix-degrading enzymes in vitroPloS oneJanuary 1, 2014Assirelli E, Pulsatelli L, Dolzani P, Platano D, Olivotto E, Filardo G, Trisolino G, Facchini A, Borzì RM, Meliconi R.

(13) Platelet ITAM signaling is critical for vascular integrity in inflammationThe Journal of clinical investigationFebruary 1, 2013Boulaftali Y, Hess PR, Getz TM, Cholka A, Stolla M, Mackman N, Owens AP 3rd, Ware J, Kahn ML, Bergmeier W.

(14) Construction and application of elastin like polypeptide containing IL-4 receptor targeting peptidePloS oneJanuary 1, 2013Sarangthem V, Cho EA, Bae SM, Singh TD, Kim SJ, Kim S, Jeon WB, Lee BH, Park RW.

(15) Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sortingThe Journal of biological chemistryApril 29, 2011Amano Y, Yamashita Y, Kojima K, Yoshino K, Tanaka N, Sugamura K, Takeshita T.

(16) Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, CB1 receptor expression and regulation by IL-4PloS oneAugust 19, 2010Thors L, Bergh A, Persson E, Hammarsten P, Stattin P, Egevad L, Granfors T, Fowler CJ.

(17) Th2 cytokine-induced upregulation of 11beta-hydroxysteroid dehydrogenase-1 facilitates glucocorticoid suppression of proasthmatic airway smooth muscle functionAmerican journal of physiology. Lung cellular and molecular physiologyMay 1, 2009Hu A, Fatma S, Cao J, Grunstein JS, Nino G, Grumbach Y, Grunstein MM.

(18) IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune responseThe Journal of allergy and clinical immunologyJanuary 1, 2009Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A.

(19) Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathwayLaboratory investigation; a journal of technical methods and pathologySeptember 1, 2008Aoudjehane L, Pissaia A Jr, Scatton O, Podevin P, Massault PP, Chouzenoux S, Soubrane O, Calmus Y, Conti F.

(20) Interleukin-4 induces human hepatocyte apoptosis through a Fas-independent pathwayFASEB journal : official publication of the Federation of American Societies for Experimental BiologyMay 1, 2007Aoudjehane L, Podevin P, Scatton O, Jaffray P, Dusanter-Fourt I, Feldmann G, Massault PP, Grira L, Bringuier A, Dousset B, et al.

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IL-4R alpha Antibody

IL-4R alpha Antibody

IL-4R alpha Antibody

IL-4R alpha Antibody

IL-4R alpha Antibody

IL-4R alpha Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (24)

Reviews

IL-4R alpha Antibody from R&D Systems, a Bio-Techne Brand

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